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Program - 2021

Maurice McGregor Cardiovascular Research Day

8:30 - 8:40

Introduction

Negareh Mousavi, MD MHSc
8:40 - 8:45 Opening Remarks Ernesto L. Schiffrin, C.M., MD, PhD, FRSC, FRCPC, FACP, FAHA
Physician-in-Chief, Department of Medicine, Jewish General Hospital
Director, Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research
Distinguished James Â鶹ԼÅÄ Professor and Vice-Chair (Research), Department of Medicine, Â鶹ԼÅÄ
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8:45 - 10:15

Oral Presentations - Session #1

Moderator: Negareh Mousavi, MD MHSc

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8:45Ìý
Diana Di Iorio:Ìý ÌýThe Role of Sex Hormones in Plaque Instability in Men and Women with Carotid Disease

Learning Objectives
1. Distinguish between stable and unstable atherosclerotic plaques.
2. Interpret the differences between men and women in relation to stroke risk and carotid plaque instability.
3. Describe differences in sex hormone receptor expression in stable and unstable atherosclerotic plaques.
4. Recognize the importance of considering sex as biological variable in atherosclerosis.

9:00
Rosie Fountotos:ÌýÌýPrognostic Value of Handgrip Strength in Older Adults Undergoing Cardiac Surgery

PDF icon Fountotos
Learning Objectives
1. Understand the need for rapid frailty testing in hospitalized older adults undergoing cardiac surgery.
2. Understand the prognostic value of handgrip strength (HGS) in older adults undergoing cardiac surgery.
3. Understand the therapeutic role of HGS in a clinical acute care setting.

9:15
Ahmad Mahmoud:Ìý Role of Vγ6+ γδ T Cells in Angiotensin II-Induced Hypertension and Vascular Injury

PDF icon Mahmoud
Learning Objectives
1. Understanding that γδ T cells play a role in angiotensin II-induced blood pressure elevation, endothelial dysfunction and T cell activation in mice.
2. Identifying the TCR Vγ6+ γδ T cells as the γδ T cell variant γ playing a role in angiotensin II-induced hypertension and vascular injury.

9:30
Justin Miron:ÌýÌýExome-Wide Association Study Identifies Rare Protein-Coding Variants for Aortic Stenosis
PDF icon Miron
Learning Objectives
1. Learn about the genetic etiology of aortic stenosis;
2. Understand the role of next-generation sequencing technologies in discovering important genetic variants and elucidating biological mechanisms that lead to cardiovascular diseases;
3. Realize the potential importance of rare protein-coding non-synonymous variants in the genetic etiology of aortic stenosis.

9:45
Amir Razaghizad:ÌýÌýValidation of the Thrombolysis in Myocardial Infarction Risk Score for Heart Failure in Diabetes (TRS-HFDM) in Patients with Recent Acute Coronary Syndrome: An Analysis of the EXAMINE Trial
PDF icon Razaghizad
Learning Objectives
1. Name antihyperglycemic medications for reducing the risk of acute heart failure events.
2. Implement a simple prediction tool to evaluate the risk of hospital admissions for heart failure in patients with diabetes.
3. Easily discriminate between patients at low- and high-risk of heart failure events to adjust or initiate appropriate antihyperglycemic care.

10:00
Carlos-Eduardo Guerrero-Chalela:ÌýÌýSevere Fontan Associated Liver Disease and its Association with Mortality
PDF icon Guerrero-Chalela
Learning Objectives
1.ÌýBuild-up knowledge and awareness on Fontan Associated Liver Disease (FALD).
2.ÌýBe aware of the relationship that FALD has with mortality.
3.ÌýRecognize risk factors of FALD to enable early recognition and prevention/treatment.
4. Provide a framework for research in congestive hepatopathy.

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Break

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10:30 - 12:00

Oral Presentations - Session #2

Moderator:ÌýAriane Marelli MD, MPH, FRCPC, FACC, FAHA

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10:30
Sabin Filimon:ÌýÌýA Meta-analysis of Short-term Mortality Rate Among White and Black Women with Acute Coronary Syndrome
PDF icon Filimon
Learning Objectives
1. Recognize that cardiovascular disease remains the leading cause of death among women
2. Recognize that, to date, there is limited data comparing mortality of white and black women post acute coronary syndrome, making it difficult to draw firm conclusions concerning the racial risk of cardiovascular disease
3. Recognize that, compared to white women, black women have higher percentages of hypertension and diabetes, and have acute coronary syndrome at a younger age
4. Recognize that black women might require a tailored approach with tighter control of hypertension and diabetes

10:45
Punnanee Wutthigate:ÌýÌýEchocardiographic markers in early postnatal life to predict intervention in coarctation of aorta

PDF icon Wutthigate
Learning Objectives
1. Recall Echocardiographic markers in antenatal suspicion of Coarctation of the aorta (CoA) to help predicting those with true CoA requiring intervention.

11:00
Ida Derish:ÌýÌýAmniotic Mesenchymal Stem Cell Spheroid-Derived Secretome as a Cell-Free Therapy to Improve Angiogenesis in Cardiovascular Repair

PDF icon Derish
Learning Objectives
1. Grasp the limitations of stem cell therapies in cardiovascular repair.
2. Understand the benefits of cell-free therapies over conventional stem cell cardiac regeneration therapies.
3. Review the advantages of using amniotic stromal mesenchymal stem cells (ASMCs) as a stem cell source for cardiovascular regenerative applications.
4. Discuss the potential of utilizing 3D ASMC culture-derived secretome in boosting angiogenic processes in human cardiac endothelial cells.

11:15
Iulia Iatan:ÌýÌý
A Clinically Validated Genetic Screening for Familial Hypercholesterolemia in Québec
PDF icon Iatan
Learning Objectives
1. Describe the Canadian definition of familial hypercholesterolemia (FH)
2. Recognize the main pathogenic FH mutations and compare them with the genetic screening offered by Quebec’s Health Ministry
3. Understand the utility and impact of genetic testing in the re-classification of patients with a clinical diagnosis of FH

11:30
Amanpreet Kaur:ÌýÌýRole of Genetics in Differences on Sex specific Effects of Clopidogrel

PDF icon Kaur
Learning Objectives
1. D
escribe aÌýsex-specific impactÌýofÌýgeneticsÌýin the safety and efficacy ofÌýantiplatelet agentsÌýin explainingÌýworse clinical outcomes in women
2.ÌýInterpret the role ofÌýCYP loss-of-functionÌýalleles inÌýhigher riskÌýofÌýadverse clinical outcomesÌýin youngÌýfemalesÌýas compared with males.

11:45
Katerina Eyre:ÌýÌýThe Clinical Utility of a Novel, Multi-parametric, Contrast-Free CMR Imaging Technique to Acquire Tissue Characterization Properties

PDF icon Eyre
Learning Objectives
1. To understand what a typical clinical CMR exam consists ofÌý
2. To understand the limitations of clinical CMR
3. To understand (at a high level) the potential impact of a novel CMR sequence: Multitasking

12:00 - 1:00

Nanette K. Wenger, MD, MACC, MACP, FAHA

Professor of Medicine (Cardiology)
Emory University School of Medicine
Consultant, Emory Heart & Vascular Center
Founding Consultant, Emory Women’s Heart Center
Atlanta, Georgia

Understanding the Journey: The Past, Present and Future of CVD in Women
PDF icon Wenger
Learning Objectives
1. Understand the journey about CVD in women.
2. Know the advances in provision of information about CVD in women in the past decade.
3. Know the knowledge gaps and research agenda to provide optimal CV care for women.

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1:00 - 2:00

Poster Presentations - Session #3

Clink link below

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Virtual poster presentations: Ìý(log in required)

Finalists

1:00 - Pouria Alipour:ÌýSex, Gender Factors and Cardiovascular Health in Canadian and Austrian populations

1:10 - Fayeza Ahmad:ÌýInitial Experience of the TARGET-EFT Trial in Frail and Pre-Frail Cardiovascular Inpatients

1:20 - Kevin Comeau:ÌýThe Role of Memory Gamma Delta T Cells in Hypertension and Vascular Damage

1:30 - Katherine Lindsay:ÌýValue of Deep Learning (ESPIRiT) for Improving the Subjective Quality of Highly Undersampled Cine CMR Images

1:40 - Karina Gasbarrino:ÌýCirculating Total Adiponectin is Strongly Associated with Increased Cholesterol Efflux Capacity in Patients with Severe Carotid Atherosclerosis

1:50 - Isabella Bozzo:ÌýMechanical characterization of the dynamics of human aortas on a mock-circulatory loop

2:00 - 2:15

Awards:Ìý

Awards will be announced by Michael Goldfarb, MD MSc
2:15 - 2:30

Closing remarks

Ariane Marelli MD, MPH, FRCPC, FACC, FAHA
Professor of Medicine, Â鶹ԼÅÄ
Founder, Â鶹ԼÅÄ Adult Unit for Congenital Heart DiseaseÌý
Director of Research and Academic Affairs
Cardiology, Â鶹ԼÅÄ Health Center

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